Anergic
Definition
In a state of anergy; characterized by the total lack or severe diminution of an organism's immune reactivity when exposed to specific antigens. Clinically, the term describes the state of a patient whose T or B lymphocytes structurally fail to generate a normal inflammatory or defensive response, a phenomenon observed in immunodeficiencies, terminal stages of chronic diseases, or following aggressive immunosuppressive therapies.
Bilingual Equivalents
- Anergic
- Non-reactive
Grammatical & Source Details
| Inflection Type | Variable adjective with standard masculine, feminine, and structural plural variations. |
| Formation | International scientific neologism functionally derived from the core pathological root of anergy. |
| Spelling / Pronunciation | [a.ner.ˈd͡ʒik] |
| Source | Handbook of Advanced Immunology and Cellular Pathophysiology |
Contextual Usage Examples
RO: Pacientul anergic nu a dezvoltat nicio reacție cutanată locală în urma administrării testului la tuberculină.
EN: The anergic patient did not develop any local skin reaction following the administration of the tuberculin test.
RO: O clonă celulară anergică rămâne în circulație, dar este complet incapabilă să atace țesuturile organismului.
EN: An anergic cell clone remains in circulation but is completely incapable of attacking the organism's tissues.
RO: Starea sa generală anergică a fost exacerbată de chimioterapia intensă suferită în ultimele luni de tratament.
EN: His general anergic state was exacerbated by the intense chemotherapy undergone during the last months of treatment.
Idioms & Phrases
Pacient cu profil anergic / Anergic profile patient
RO: Persoană care prezintă o prăbușire a imunității celulare, demonstrată prin absența răspunsului la panelul de antigene standard.
EN: An individual exhibiting a collapse of cellular immunity, demonstrated by the lack of response to a standard antigen panel.
Limfocit T anergic / Anergic T cell
RO: Celulă a sistemului imunitar inactivată funcțional din cauza lipsei semnalelor de costimulare necesare activării.
EN: An immune system cell functionally inactivated due to the lack of costimulatory signals required for activation.
Răspuns de tip anergic / Anergic-type response
RO: Manifestare patologică în care organismul tolerează un agent patogen invaziv fără a declanșa mecanisme de apărare.
EN: A pathological manifestation where the body tolerates an invasive pathogen without triggering defense mechanisms.
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