#immune tolerance

• Anergic — In a state of anergy; characterized by the total lack or severe diminution of an organism's immune reactivity when exposed to specific antigens. Clinically, the term describes the state of a patient whose T or B lymphocytes structurally fail to generate a normal inflammatory or defensive response, a phenomenon observed in immunodeficiencies, terminal stages of chronic diseases, or following aggressive immunosuppressive therapies.
• Anergy — A pathological or physiological state characterized by the total absence or severe diminution of the body's reactivity (especially of the immune system) when exposed to antigens, allergens, or external stimuli. In cellular immunology, it represents a mechanism of peripheral tolerance where lymphocytes become functionally inactivated following interaction with an antigen, failing to trigger an inflammatory or defensive response.
• Autoantigen — A normal molecular constituent, macromolecule, protein, or cellular structure native to an organism that, under conditions of impaired immune tolerance, is erroneously recognized as a foreign substance (antigen) and becomes the target of an attack triggered by its own immune system.