Amidopyrine
Definition
A medicinal compound from the pyrazolone class, historically used as a potent analgesic, antipyretic, and anti-inflammatory agent, chemically known as aminophenazone. Although it possesses high structural efficiency in combating fever and acute pain, its modern clinical use has been severely restricted or banned in most countries due to the documented risk of inducing severe agranulocytosis and the formation of carcinogenic nitrosamines in the stomach.
Bilingual Equivalents
- Amidopyrine
- Aminophenazone
Grammatical & Source Details
| Inflection Type | Feminine noun, regular chemical substance nomenclature variations. |
| Formation | Pharmacological blending of the prefix 'amido-' representing the nitrogen group and the root '-pyrine' derived from antipyrine. |
| Spelling / Pronunciation | [ə.ˌmɪ.doʊ.ˈpaɪ.riːn] |
| Source | United States Pharmacopeia Historical Index |
Contextual Usage Examples
RO: În secolul trecut, tabletele de amidopirină erau prescrise în mod frecvent pentru tratarea reumatismului articular acut.
EN: In the last century, amidopyrine tablets were frequently prescribed for the treatment of acute rheumatic fever.
RO: Deoarece pacientul a dezvoltat o toxicitate medulară severă, medicul a interzis imediat administrarea de amidopirină.
EN: Because the patient developed severe bone marrow toxicity, the doctor immediately prohibited the administration of amidopyrine.
RO: Laboratorul toxicologic a identificat urme de amidopirină într-un preparat farmaceutic vechi, nerespectând normele actuale.
EN: The toxicological laboratory identified traces of amidopyrine in an old pharmaceutical preparation, violating current standards.
Idioms & Phrases
Toxicitate prin amidopirină / Amidopyrine toxicity
RO: Efect advers sever caracterizat prin distrugerea celulelor granulocitare din sânge, lăsând organismul vulnerabil la infecții.
EN: A severe adverse effect characterized by the destruction of granulocyte cells in the blood, leaving the body vulnerable to infections.
Testul respirator cu amidopirină / Amidopyrine breath test
RO: Metodă istorică de diagnostic clinic folosită pentru a evalua funcția metabolică a ficatului prin măsurarea eliminării de dioxid de carbon marcat.
EN: A historical clinical diagnostic method used to assess the metabolic function of the liver by measuring the elimination of labeled carbon dioxide.
Derivat de amidopirină / Amidopyrine derivative
RO: Substanță modificată structural în laborator cu scopul de a păstra efectul analgezic fără a induce agranulocitoză secundară.
EN: A substance structurally modified in the laboratory with the aim of preserving the analgesic effect without inducing secondary agranulocytosis.
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