#igf-1 excess
- Acromegaly — A chronic neuroendocrine disease caused by a pathological hypersecretion of growth hormone (somatotropin) and insulin-like growth factor (IGF-1) in adulthood, after the closure of epiphyseal growth plates. The condition is characterized by the exaggerated enlargement of skeletal extremities (hands, feet), hypertrophy of facial bones (prognatism, prominent brow ridges), soft tissue thickening, macroglossia, and secondary severe cardiac or metabolic dysfunctions.