#acromegaly

• Acromegalic — Suffering from acromegaly; characterized by the excessive and disproportionate development of the body's extremities (hands, feet, facial bones, nose, jaw) due to the pathological hypersecretion of growth hormone (somatotropin) after the closure of epiphyseal plates. As a noun, it designates a male individual clinically diagnosed with this chronic neuroendocrine condition, most commonly triggered by a pituitary adenoma.
• Acromegalic — A synonymous variant of the adjective acromegal; relating to acromegaly, manifesting its symptoms, or affected by the hypersecretion of somatotropin. As a noun, the term defines a male individual presenting the clinical picture of the disease, marked by hypertrophy of the facial bones, hands, and feet secondary to a pituitary adenoma.
• Acromegaly — A chronic neuroendocrine disease caused by a pathological hypersecretion of growth hormone (somatotropin) and insulin-like growth factor (IGF-1) in adulthood, after the closure of epiphyseal growth plates. The condition is characterized by the exaggerated enlargement of skeletal extremities (hands, feet), hypertrophy of facial bones (prognatism, prominent brow ridges), soft tissue thickening, macroglossia, and secondary severe cardiac or metabolic dysfunctions.