Antitrypsin
Definition
A plasma glycoprotein synthesized primarily by liver cells, having the essential physiological role of inhibiting the activity of proteolytic enzymes, especially trypsin and neutrophil elastase. The most prominent representative of this class is alpha-1-antitrypsin, a macromolecular substance that protects fragile lung tissue against self-destructive enzymatic degradation, its genetic deficiency being directly linked to early-onset pulmonary emphysema and liver cirrhosis.
Bilingual Equivalents
- Antitrypsin
- Alpha-1-antitrypsin
Grammatical & Source Details
| Inflection Type | Feminine noun, regular declension with standard structural plural modifications in Romanian. |
| Formation | Derived through biochemical prefixation, combining the oppositional modifier 'anti-' with the enzyme name 'trypsin'. |
| Spelling / Pronunciation | [an.ti.trip.ˈsi.nə] |
| Source | The Merck Index and International Glossary of Biochemical Terms |
Contextual Usage Examples
RO: Medicul a solicitat dozarea de alfa-1-antitripsină din sânge pentru a exclude o boală pulmonară ereditară.
EN: The physician requested blood alpha-1-antitrypsin quantification to rule out a hereditary lung disease.
RO: Această antitrypsină blochează eficient elastaza care altfel ar distruge alveolele pulmonare.
EN: This antitrypsin efficiently blocks elastase which would otherwise destroy the pulmonary alveoli.
RO: Producția scăzută de antitrypsină în hepatocite este cauzată de o mutație genetică structurală.
EN: The low production of antitrypsin in hepatocytes is caused by a structural genetic mutation.
Idioms & Phrases
Deficit congenital de antitrypsină / Congenital antitrypsin deficiency
RO: Afecțiune genetică rară care predispune organismul la distrugerea prematură a țesuturilor elastice din plămâni.
EN: A rare genetic disorder that predisposes the body to premature destruction of elastic tissues in the lungs.
Activitate inhibitorie antitripsină / Antitrypsin inhibitory activity
RO: Unitate de măsură de laborator ce indică capacitatea plasmei de a neutraliza o cantitate standard de enzimă activă.
EN: A laboratory measurement unit indicating the capacity of plasma to neutralize a standard amount of active enzyme.
Antitripsină purificată de sinteză / Purified synthetic antitrypsin
RO: Preparat farmaceutic de ultimă generație administrat intravenos pacienților pentru substituție hormonală sau enzimatică.
EN: A state-of-the-art pharmaceutical preparation administered intravenously to patients for hormone or enzyme replacement.
Latest Contextual News
No recent news found for this topic.