Antioncogene
Definition
A tumor suppressor gene whose normal function is to negatively control cell proliferation, repair DNA errors, or trigger apoptosis, thereby preventing malignant transformation of cells; in an adjective sense, it describes a mechanism, protein, or therapy capable of counteracting oncogene action and inhibiting cancer development.
Bilingual Equivalents
- Antioncogene
- Tumor suppressor gene
Grammatical & Source Details
| Inflection Type | Masculine scientific noun or variable descriptive adjective with standard biological plural variations. |
| Formation | Formed through prefixation by adding 'anti-' to the established medical term 'oncogene'. |
| Spelling / Pronunciation | [ˌæn.tiˌɒŋ.koʊˈdʒiːn] |
| Source | Emery's Elements of Medical Genetics and Molecular Oncology |
Contextual Usage Examples
RO: Inactivarea prin mutație a unui antioncogen esențial lasă celula lipsită de mecanismul de frânare a diviziunii.
EN: The inactivation by mutation of an essential antioncogene leaves the cell without its division braking mechanism.
RO: Gena p53 este considerată cel mai faimos antioncogen datorită rolului său de gardian al genomului celular.
EN: The p53 gene is considered the most famous antioncogene due to its role as the guardian of the cellular genome.
RO: Terapia genetică experimentală încearcă să reintroducă un antioncogen funcțional în interiorul celulelor tumorale.
EN: Experimental gene therapy attempts to reintroduce a functional antioncogene inside tumor cells.
Idioms & Phrases
Mutație a antioncogenului / Antioncogene mutation
RO: Modificare dăunătoare în secvența de nucleotide care duce la pierderea funcției de supresie tumorală.
EN: A harmful alteration in the nucleotide sequence that leads to the loss of tumor suppression function.
Activitate antioncogenă / Antioncogenic activity
RO: Capacitatea fiziologică a unor proteine de a opri ciclul celular atunci când detectează leziuni ale structurii ADN.
EN: The physiological capacity of certain proteins to halt the cell cycle when they detect DNA structure damage.
Locus antioncogen / Antioncogene locus
RO: Poziția fixă pe un cromozom unde este situată o genă responsabilă de prevenirea malignizării celulare.
EN: The fixed position on a chromosome where a gene responsible for preventing cellular malignancy is located.
Latest Contextual News
No recent news found for this topic.