Amyloidosis
Definition
A systemic or localized metabolic and progressive disorder characterized by the abnormal deposition of amyloid (faultily folded insoluble proteins in beta-sheets) within the extracellular spaces of vital organs, such as the kidneys, heart, liver, or nervous system. This structural accumulation causes progressive atrophy of the cellular parenchyma and severe dysfunctions or organ failures, classified into primary, secondary, hereditary, or aging-associated forms.
Bilingual Equivalents
- Amyloidosis
- Amyloid disease
Grammatical & Source Details
| Inflection Type | Feminine noun, regular singular and plural inflections used in standard international medical classification. |
| Formation | Derived from the base term 'amyloid' combined with the medical structural suffix '-osis' (diseased condition). |
| Spelling / Pronunciation | [a.mi.loi.ˈdo.zə] |
| Source | Harrison's Principles of Internal Medicine and Pathology Guidelines |
Contextual Usage Examples
RO: Diagnosticul cert de amiloidoză renală a fost stabilit abia după efectuarea unei biopsii și colorarea țesutului cu Roșu de Congo.
EN: The definitive diagnosis of renal amyloidosis was established only after performing a biopsy and staining the tissue with Congo Red.
RO: Această formă de amiloidoză secundară poate să apară ca o complicație a unor infecții cronice netratate sau a artritei reumatoide.
EN: This form of secondary amyloidosis can occur as a complication of untreated chronic infections or rheumatoid arthritis.
RO: Medicii monitorizează funcția cardiacă a pacientului pentru a evalua dacă o amiloidoză sistemică a afectat miocardul.
EN: Doctors are monitoring the patient's cardiac function to evaluate whether a systemic amyloidosis has affected the myocardium.
Idioms & Phrases
Amiloidoză sistemică / Systemic amyloidosis
RO: Formă generalizată a bolii în care agregatele proteice circulă prin sânge și se depun simultan în multiple organe din corp.
EN: A generalized form of the disease where protein aggregates circulate through the blood and deposit simultaneously in multiple body organs.
Amiloidoză ereditară / Hereditary amyloidosis
RO: Afecțiune genetică rară transmisă autozomal, determinată de mutații ale unor proteine hepatice precum transtiretina.
EN: A rare genetically transmitted autosomal disorder caused by mutations in certain liver proteins such as transthyretin.
Amiloidoză primară / Primary amyloidosis
RO: Tip de disfuncție medulară legată de producția excesivă de lanțuri ușoare de imunoglobuline de către celulele plasmatice.
EN: A type of bone marrow dysfunction linked to the excessive production of immunoglobulin light chains by plasma cells.
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