#sadness

• Affliction — A state of profound moral pain, oppressive sadness, grief, or soul-crushing suffering caused by a great misfortune. In a modern psychological sense, it describes an intense emotional experience of mourning or despair, manifested as an inner collapse.
• Bitterness — An unpleasant bitter gustatory sensation felt in the mouth, caused by gastric disorders, biliary conditions, or the consumption of certain foods or medications. Figuratively, the term describes an emotional state of deep sadness, bitterness, trouble, or grief triggered by life's hardships or a major disappointment; also, in botany, it represents a popular name for the medicinal plant bitter milkwort.
• Bitterness — An archaic or regional term designating the quality of being bitter, the intensely unpleasant taste of a substance, or the intensity of a bitter sensation. Figuratively, in old texts or popular dialects, the term defines a profound state of trouble, grief, despair, or a moral suffering hard to endure.