#irritation

• Abietin — A term used in early pharmaceutical chemistry to describe a bitter principle, resinous substance, or glycoside extracted from the bark and needles of certain conifer species (genus Abies). In past centuries, researchers analyzed abietin for its febrifuge (fever-reducing) and stimulant potential, but overdosing concentrated remedies containing this compound could cause acute gastric irritation or toxic nephritis.
• Annoyance — The act of annoying and its result; a state of irritation, vexation, nagging, or psychological discomfort triggered by an external disruptive factor. Structurally, it represents a verbal noun of action expressing the process through which a person is repeatedly subjected to negative stimuli, leading to a loss of patience or calm.